Antioxidant vitamins did not reduce death, vascular events, or cancer in high risk patients

Trandolapril did not reduce cardiovascular death or other events in stable coronary artery disease.

and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr E Braunwald, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA. [email protected] Sources of funding: National Heart, Lung and Blood Institute; Knoll Pharmaceuticals; Abbott L...

ACP Journal Club. Telemonitoring did not reduce hospitalizations or ED visits in high-risk elderly patients.

Lowering homocysteine with folic acid and B vitamins did not prevent vascular events in vascular disease.

M e t h o d s Design: Randomized placebo-controlled trial (Heart Outcomes Prevention Evaluation [HOPE] 2 trial). Allocation: Concealed.* Blinding: Blinded {clinicians, patients, data collectors, outcome assessors, and data analysts}†.* Follow-up period: Mean 5 years. Setting: 145 centers in 13 countries (Canada, United States, Brazil, western Europe, and Slovakia). Patients: 5522 patients ≥ 55 ...

Antioxidant Vitamins Reduce the Risk for Cancer: Part One

Introduction The published scientific evidence that increased consumption of antioxidant vitamins, vitamins C and E, reduces the risk of cancer has been growing over the last several decades. This review assesses the evidence that was reviewed previously by the Food and Drug Administration along with the evidence that has appeared since that review was completed. The conclusions that are drawn ...

Atorvastatin did not prevent cardiovascular events or death in patients with type 2 diabetes receiving hemodialysis.